De Quervain's tenosynovitis is a painful condition affecting the tendons on the thumb side of the wrist, mainly the abductor pollicis longus (APL) and extensor pollicis brevis (EPB). It usually occurs due to repetitive thumb movements, lifting, or overuse of the wrist. A physiotherapist plays a very important role in reducing pain, restoring thumb–wrist movement, and preventing recurrence. 1. Pain and Inflammation Control 2. Immobilization and Protection 3. Improving Range of Motion (ROM) 4. Strengthening Exercises 5. Stretching Exercises 6. Ergonomic and Activity Modification 7. Functional Rehabilitation